COLON TARGETED BEADS LOADED WITH PTEROSTILBENE: FORMULATION, OPTIMIZATION, CHARACTERIZATION AND IN VIVO EVALUATION

Colon targeted beads loaded with pterostilbene: Formulation, optimization, characterization and in vivo evaluation

Background: Pterostilbene has a proven chemopreventive effect for colon carcinogenesis but suffers low bioavailability limitations and therefore unable to reach the colonic tissue.Objective and methodology: To overcome the issue of low bioavailability, pterostilbene was formulated into an oral colon targeted beads by ionic gelation method using pec

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Trial registration as a safeguard against outcome reporting bias and spin? A case study of randomized controlled trials of acupuncture.

BACKGROUND AND OBJECTIVE:Trial registration is widely endorsed as it is considered not only to enhance transparency and quality of reporting but also to help safeguard against outcome reporting bias and probably spin, known as specific reporting that could distort the interpretation of results thus mislead readers.We planned to investigate the curr

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Practicing COVID-19 Public Health Measures Is Associated With Anxiety and Depression in Undergraduate University Students

BackgroundCOVID-19 has affected mental health globally, increasing depression and anxiety.This study examined relationships between practicing COVID-19-related public health measures and depression and anxiety in young adult students.MethodsA sample of 755 undergraduate students 18–25 years of age at a large public university completed a cross-se

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The effects of Positive Youth Development interventions on substance use, violence and inequalities: systematic review of theories of change, processes and outcomes

Background: Positive Youth Development (PYD) delivered outside school aims to enable young people to develop Integrated Fridge/Freezers positive assets such as relationships and confidence, rather than to merely address risk.Existing reviews of PYD effects on substance use or violence are old and unsystematic.Objectives: To systematically review ev

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